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BMCBI
2008
84views more  BMCBI 2008»
13 years 7 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
BMCBI
2006
195views more  BMCBI 2006»
13 years 7 months ago
CAFTAN: a tool for fast mapping, and quality assessment of cDNAs
Background: The German cDNA Consortium has been cloning full length cDNAs and continued with their exploitation in protein localization experiments and cellular assays. However, t...
Coral del Val, Vladimir Yurjevich Kuryshev, Karl-H...
BMCBI
2006
95views more  BMCBI 2006»
13 years 7 months ago
A quantitative analysis of secondary RNA structure using domination based parameters on trees
Background: It has become increasingly apparent that a comprehensive database of RNA motifs is essential in order to achieve new goals in genomic and proteomic research. Secondary...
Teresa W. Haynes, Debra J. Knisley, Edith Seier, Y...
JIB
2006
106views more  JIB 2006»
13 years 7 months ago
A structural keystone for drug design
3D-structures of proteins and potential ligands are the cornerstones of rational drug design. The first brick to build upon is selecting a protein target and finding out whether b...
Kristian Rother, Mathias Dunkel, Elke Michalsky, S...
HICSS
2007
IEEE
183views Biometrics» more  HICSS 2007»
14 years 1 months ago
Rescuing Small and Medium-Sized Enterprises from Inefficient Information Systems - A Multi-disciplinary Method for ERP System Re
Enterprise resource planning (ERP) systems integrate companies’ multiple information systems and help adapt best practices for business processes. ERP systems are in most cases ...
Inka Vilpola, Ilkka Kouri, Kaisa Vään&au...