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BMCBI
2008
94views more  BMCBI 2008»
15 years 4 months ago
A comprehensive re-analysis of the Golden Spike data: Towards a benchmark for differential expression methods
Background: The Golden Spike data set has been used to validate a number of methods for summarizing Affymetrix data sets, sometimes with seemingly contradictory results. Much less...
Richard D. Pearson
BMCBI
2008
132views more  BMCBI 2008»
15 years 4 months ago
Mixture models for analysis of melting temperature data
Background: In addition to their use in detecting undesired real-time PCR products, melting temperatures are useful for detecting variations in the desired target sequences. Metho...
Christoffer Nellåker, Fredrik Uhrzander, Joa...
BMCBI
2008
86views more  BMCBI 2008»
15 years 4 months ago
Subfamily specific conservation profiles for proteins based on n-gram patterns
Background: A new algorithm has been developed for generating conservation profiles that reflect the evolutionary history of the subfamily associated with a query sequence. It is ...
John K. Vries, Xiong Liu
BMCBI
2008
88views more  BMCBI 2008»
15 years 4 months ago
Microarray-based gene set analysis: a comparison of current methods
Background: The analysis of gene sets has become a popular topic in recent times, with researchers attempting to improve the interpretability and reproducibility of their microarr...
Sarah Song, Michael A. Black
BMCBI
2008
129views more  BMCBI 2008»
15 years 4 months ago
Gene set enrichment analysis for non-monotone association and multiple experimental categories
Background: Recently, microarray data analyses using functional pathway information, e.g., gene set enrichment analysis (GSEA) and significance analysis of function and expression...
Rongheng Lin, Shuangshuang Dai, Richard D. Irwin, ...
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