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BMCBI
2010
208views more  BMCBI 2010»
13 years 10 months ago
Using machine learning to speed up manual image annotation: application to a 3D imaging protocol for measuring single cell gene
Background: Image analysis is an essential component in many biological experiments that study gene expression, cell cycle progression, and protein localization. A protocol for tr...
Zafer Aydin, John I. Murray, Robert H. Waterston, ...
BMCBI
2010
118views more  BMCBI 2010»
13 years 10 months ago
svdPPCS: an effective singular value decomposition-based method for conserved and divergent co-expression gene module identifica
Background: Comparative analysis of gene expression profiling of multiple biological categories, such as different species of organisms or different kinds of tissue, promises to e...
Wensheng Zhang, Andrea Edwards, Wei Fan, Dongxiao ...
BMCBI
2010
110views more  BMCBI 2010»
13 years 10 months ago
OLS Dialog: An open-source front end to the Ontology Lookup Service
Background: With the growing amount of biomedical data available in public databases it has become increasingly important to annotate data in a consistent way in order to allow ea...
Harald Barsnes, Richard G. Côté, Ingv...
BMCBI
2010
84views more  BMCBI 2010»
13 years 10 months ago
A variational Bayes algorithm for fast and accurate multiple locus genome-wide association analysis
Background: The success achieved by genome-wide association (GWA) studies in the identification of candidate loci for complex diseases has been accompanied by an inability to expl...
Benjamin A. Logsdon, Gabriel E. Hoffman, Jason G. ...
BMCBI
2010
137views more  BMCBI 2010»
13 years 10 months ago
Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments
Background: While the pairwise alignments produced by sequence similarity searches are a powerful tool for identifying homologous proteins - proteins that share a common ancestor ...
Michael L. Sierk, Michael E. Smoot, Ellen J. Bass,...