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BMCBI
2010
183views more  BMCBI 2010»
13 years 7 months ago
SOPRA: Scaffolding algorithm for paired reads via statistical optimization
Background: High throughput sequencing (HTS) platforms produce gigabases of short read (<100 bp) data per run. While these short reads are adequate for resequencing application...
Adel Dayarian, Todd P. Michael, Anirvan M. Sengupt...
BMCBI
2010
84views more  BMCBI 2010»
13 years 7 months ago
Testing the additional predictive value of high-dimensional molecular data
Background: While high-dimensional molecular data such as microarray gene expression data have been used for disease outcome prediction or diagnosis purposes for about ten years i...
Anne-Laure Boulesteix, Torsten Hothorn
BMCBI
2010
126views more  BMCBI 2010»
13 years 7 months ago
A boosting method for maximizing the partial area under the ROC curve
Background: The receiver operating characteristic (ROC) curve is a fundamental tool to assess the discriminant performance for not only a single marker but also a score function c...
Osamu Komori, Shinto Eguchi
BMCBI
2010
89views more  BMCBI 2010»
13 years 7 months ago
Enhancing metabolomic data analysis with Progressive Consensus Alignment of NMR Spectra (PCANS)
Background: Nuclear magnetic resonance spectroscopy is one of the primary tools in metabolomics analyses, where it is used to track and quantify changes in metabolite concentratio...
Jennifer M. Staab, Thomas M. O'Connell, Shawn M. G...
BMCBI
2010
112views more  BMCBI 2010»
13 years 7 months ago
A parameter-adaptive dynamic programming approach for inferring cophylogenies
Background: Coevolutionary systems like hosts and their parasites are commonly used model systems for evolutionary studies. Inferring the coevolutionary history based on given phy...
Daniel Merkle, Martin Middendorf, Nicolas Wieseke