Genome sequencing opened a new era in genetics allowing the study of genomes at the nucleotide level. However, the chosen method of sequencing produced large numbers of nucleotide...
In microarray classification we are faced with a very large number of features and very few training samples. This is a challenge for classical Linear Discriminant Analysis (LDA),...
Roger Pique-Regi, Antonio Ortega, Shahab Asgharzad...
In our effort to elucidate the systems biology of the model organism, Escherichia coli, we have developed a mathematical model that simulates the allosteric regulation for threoni...
Tarek S. Najdi, Chin-Rang Yang, Bruce E. Shapiro, ...
The classification of proteins based on their structure can play an important role in the deduction or discovery of protein function. However, the relatively low number of solved...
Keith Marsolo, Srinivasan Parthasarathy, Chris H. ...
The inverse protein folding problem is that of designing an amino acid sequence which has a prescribed native protein fold. This problem arises in drug design where a particular st...
Abstract. We propose a computational method for reconstructing metabolic networks. The method utilizes optimization techniques and graph traversal algorithms to discover a set of b...
Abstract. We describe a new method for the exploration of evolutionary relations between protein structures. The approach is based on the ESSM algorithm for detecting structural mu...