Abstract. In engineering protein variants by constructing and screening combinatorial libraries of chimeric proteins, two complementary and competing goals are desired: the new pro...
A central challenge in systems biology is the reconstruction of biological networks from high-throughput data sets. A particularly difficult case of this is the inference of dynami...
Michael Baym, Chris Bakal, Norbert Perrimon, Bonni...
High-accuracy protein structure modeling demands accurate and very fast side chain prediction since such a procedure must be repeatedly called at each step of structure refinement....
A major hindrance to studies of microbial diversity has been that the vast majority of microbes cannot be cultured in the laboratory and thus are not amenable to traditional method...
A key problem of interest to biologists and medical researchers is the selection of a subset of queries or treatments that provide maximum utility for a population of targets. For ...
Delbert Dueck, Brendan J. Frey, Nebojsa Jojic, Vla...
As an increasing number of eukaryotic genomes are being sequenced, comparative studies aimed at detecting regulatory elements in intergenic sequences are becoming more prevalent. M...