WABI
2010
Springer
13 years 9 months ago
2010
Springer
In this paper we present a novel expectation-maximization algorithm for inference of alternative splicing isoform frequencies from high-throughput transcriptome sequencing (RNA-Seq...
WABI
2010
Springer
13 years 9 months ago
2010
Springer
Abstract. The orientation of physical networks is a prime task in deciphering the signaling-regulatory circuitry of the cell. One manifestation of this computational task is as a m...
WABI
2010
Springer
13 years 9 months ago
2010
Springer
Background: Although many RNA molecules contain pseudoknots, computational prediction of pseudoknotted RNA structure is still in its infancy due to high running time and space con...
WABI
2010
Springer
13 years 9 months ago
2010
Springer
The center string (or closest string) problem is a classical computer science problem with important applications in computational biology. Given k input strings and a distance thr...
WABI
2010
Springer
13 years 9 months ago
2010
Springer
Quantification of selective pressures on regulatory sequences is a central question in studying the evolution of gene regulatory networks. Previous methods focus primarily on sing...
WABI
2010
Springer
13 years 9 months ago
2010
Springer
Abstract. Applied Biosystems’ SOLiD system offers a low-cost alternative to the traditional Sanger method of DNA sequencing. We introduce two main algorithms of mapping SOLiD’...
PRIB
2010
Springer
13 years 10 months ago
2010
Springer
We studied 1372 LacI-family transcription factors and their 4484 DNA binding sites using machine learning algorithms and feature selection techniques. The Naive Bayes classifier a...
PRIB
2010
Springer
13 years 10 months ago
2010
Springer
Abstract. Supervised classifiers require manually labeled training samples to classify unlabeled objects. Active Learning (AL) can be used to selectively label only “ambiguous...
PRIB
2010
Springer
13 years 10 months ago
2010
Springer
We present a structured output prediction approach for classifying potential anti-cancer drugs. Our QSAR model takes as input a description of a molecule and predicts the activity...
JBI
2010
13 years 10 months ago
2010
