BMCBI
2011
13 years 3 months ago
2011
Background: Comparison of the human genome with other primates offers the opportunity to detect evolutionary events that created the diverse phenotypes among the primate species. ...
BMCBI
2011
13 years 3 months ago
2011
Background: The substitution rates within different nucleotide contexts are subject to varying levels of bias. The most well known example of such bias is the excess of C to T (C ...
BMCBI
2011
13 years 3 months ago
2011
Background: Liquid chromatography-mass spectrometry (LC-MS) utilizing the high-resolution power of an orbitrap is an important analytical technique for both metabolomics and prote...
BMCBI
2011
13 years 3 months ago
2011
Background: Rapid annotation and comparisons of genomes from multiple isolates (pan-genomes) is becoming commonplace due to advances in sequencing technology. Genome annotations c...
BMCBI
2011
13 years 3 months ago
2011
Background: Current approaches for identifying transcriptional regulatory elements are mainly via the combination of two properties, the evolutionary conservation and the overrepr...
BMCBI
2011
13 years 3 months ago
2011
Background: The ability to search for and precisely compare similar phenotypic appearances within and across species has vast potential in plant science and genetic research. The ...
BMCBI
2011
13 years 3 months ago
2011
Background: The popularity of massively parallel exome and transcriptome sequencing projects demands new data mining tools with a comprehensive set of features to support a wide r...
BMCBI
2011
13 years 3 months ago
2011
Background: Gene set analysis (GSA) has become a successful tool to interpret gene expression profiles in terms of biological functions, molecular pathways, or genomic locations. ...
BMCBI
2011
13 years 3 months ago
2011
Background: Alternative splicing of pre-mature RNA is an important process eukaryotes utilize to increase their repertoire of different protein products. Several types of differen...
BMCBI
2011
13 years 3 months ago
2011
Background: Genome-wide transcriptional profiling of patient blood samples offers a powerful tool to investigate underlying disease mechanisms and personalized treatment decisions...