BMCBI
2008
13 years 11 months ago
2008
Background: Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role...
BMCBI
2008
13 years 11 months ago
2008
Background: DNA methylation is an important epigenetic modification of the genome. Abnormal DNA methylation may result in silencing of tumor suppressor genes and is common in a va...
BMCBI
2010
13 years 11 months ago
2010
Background: High-throughput DNA methylation arrays are likely to accelerate the pace of methylation biomarker discovery for a wide variety of diseases. A potential problem with a ...
BMCBI
2010
13 years 11 months ago
2010
Background: Bisulfite sequencing is a popular method to analyze DNA methylation patterns at high resolution. A region of interest is targeted by PCR and about 20-50 subcloned DNA ...
BMCBI
2010
13 years 11 months ago
2010
Background: Bisulfite sequencing using next generation sequencers yields genome-wide measurements of DNA methylation at single nucleotide resolution. Traditional aligners are not ...