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JMLR
2010
125views more  JMLR 2010»
13 years 7 months ago
On utility of gene set signatures in gene expression-based cancer class prediction
Machine learning methods that can use additional knowledge in their inference process are central to the development of integrative bioinformatics. Inclusion of background knowled...
Minca Mramor, Marko Toplak, Gregor Leban, Tomaz Cu...
JMLR
2010
133views more  JMLR 2010»
13 years 7 months ago
Hierarchical Cost-Sensitive Algorithms for Genome-Wide Gene Function Prediction
In this work we propose new ensemble methods for the hierarchical classification of gene functions. Our methods exploit the hierarchical relationships between the classes in diffe...
Nicolò Cesa-Bianchi, Giorgio Valentini
JMLR
2010
145views more  JMLR 2010»
13 years 7 months ago
Event based text mining for integrated network construction
The scientific literature is a rich and challenging data source for research in systems biology, providing numerous interactions between biological entities. Text mining technique...
Yvan Saeys, Sofie Van Landeghem, Yves Van de Peer
JMLR
2010
97views more  JMLR 2010»
13 years 7 months ago
Evaluation of a Bayesian model-based approach in GA studies
In a typical Genetic Association Study (GAS) several hundreds to millions of genomic variables are measured and tested for association with a given set of a phenotypic variables (...
Gábor Hullám, Peter Antal, Csaba Sza...
JMLR
2010
161views more  JMLR 2010»
13 years 7 months ago
Accuracy-Rejection Curves (ARCs) for Comparing Classification Methods with a Reject Option
Data extracted from microarrays are now considered an important source of knowledge about various diseases. Several studies based on microarray data and the use of receiver operat...
Malik Sajjad Ahmed Nadeem, Jean-Daniel Zucker, Bla...
JMLR
2010
105views more  JMLR 2010»
13 years 7 months ago
Evaluation of Signaling Cascades Based on the Weights from Microarray and ChIP-seq Data
In this study, we combined the ChIP-seq and the transcriptome data and integrated these data into signaling cascades. Integration was realized through a framework based on data- a...
Zerrin Isik, Volkan Atalay, Rengül Çet...
JMLR
2010
82views more  JMLR 2010»
13 years 7 months ago
TIED: An Artificially Simulated Dataset with Multiple Markov Boundaries
We present an artificially simulated dataset (TIED) constructed so that there are many minimal sets of variables with maximal predictivity (i.e., Markov boundaries) and likewise m...
Alexander R. Statnikov, Constantin F. Aliferis
JMLR
2010
117views more  JMLR 2010»
13 years 7 months ago
Comparison of Granger Causality and Phase Slope Index
We recently proposed a new measure, termed Phase Slope Index (PSI), It estimates the causal direction of interactions robustly with respect to instantaneous mixtures of independen...
Guido Nolte, Andreas Ziehe, Nicole Krämer, Fl...
JMLR
2010
134views more  JMLR 2010»
13 years 7 months ago
Inference of Graphical Causal Models: Representing the Meaningful Information of Probability Distributions
This paper studies the feasibility and interpretation of learning the causal structure from observational data with the principles behind the Kolmogorov Minimal Sufficient Statist...
Jan Lemeire, Kris Steenhaut