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PSB
2004
14 years 1 months ago
An Evidence Ontology for Use in Pathway/Genome Databases
An important emerging need in Model Organism Databases (MODs) and other bioinformatics databases (DBs) is that of capturing the scientific evidence that supports the information wi...
Peter D. Karp, Suzanne M. Paley, Cynthia J. Kriege...
APBC
2003
141views Bioinformatics» more  APBC 2003»
14 years 2 months ago
Comparison of Metabolic Pathways using Constraint Graph Drawing
Databases contain a large amount of data about metabolic pathways, in particular about similar pathways in different species. Biologists are familiar with visual representations ...
Falk Schreiber
CIBCB
2005
IEEE
14 years 2 months ago
Pathway Analyst--Automated Metabolic Pathway Prediction
—Metabolic pathways are crucial to our understanding of biology. The speed at which new organisms are being sequenced is outstripping our ability to experimentally determine thei...
Luca Pireddu, Brett Poulin, Duane Szafron, Paul Lu...
BIBM
2007
IEEE
149views Bioinformatics» more  BIBM 2007»
14 years 4 months ago
An Algorithm for Assigning Unique Keys to Metabolic Pathways
Different databases of metabolic pathways assign pathways different keys. For this reason, it is difficult to automatically compare pathways across databases. We introduce an algo...
Fang Fang, Robert L. Grossman, Xiangjun Liu
IPPS
2002
IEEE
14 years 5 months ago
Parallel Out-of-Core Algorithm for Genome-Scale Enumeration of Metabolic Systemic Pathways
Systemic pathways-oriented approaches to analysis of metabolic networks are effective for small networks but are computationally infeasible for genome scale networks. Current comp...
Nagiza F. Samatova, Al Geist, George Ostrouchov, A...
RECOMB
2010
Springer
14 years 5 months ago
SubMAP: Aligning Metabolic Pathways with Subnetwork Mappings
Abstract. We consider the problem of aligning two metabolic pathways. Unlike traditional approaches, we do not restrict the alignment to one-to-one mappings between the molecules o...
Ferhat Ay, Tamer Kahveci
GG
2004
Springer
14 years 6 months ago
Analysis of Metabolic Pathways by Graph Transformation
Biochemical pathways, such as metabolic, regulatory, and signal transduction pathways, constitute complex networks of functional and physical interactions between molecular species...
Francesc Rosselló, Gabriel Valiente
CMSB
2004
Springer
14 years 6 months ago
Modelling Metabolic Pathways Using Stochastic Logic Programs-Based Ensemble Methods
In this paper we present a methodology to estimate rates of enzymatic reactions in metabolic pathways. Our methodology is based on applying stochastic logic learning in ensemble le...
Huma Lodhi, Stephen Muggleton
GECCO
2005
Springer
124views Optimization» more  GECCO 2005»
14 years 6 months ago
Evolving petri nets to represent metabolic pathways
Given concentrations of metabolites over a sequence of time steps, the metabolic pathway prediction problem seeks a set of reactions and rate constants for them that could yield t...
Jeremiah Nummela, Bryant A. Julstrom
ICDM
2006
IEEE
152views Data Mining» more  ICDM 2006»
14 years 6 months ago
Application of Graph-based Data Mining to Metabolic Pathways
We present a method for finding biologically meaningful patterns on metabolic pathways using the SUBDUE graph-based relational learning system. A huge amount of biological data t...
Chang Hun You, Lawrence B. Holder, Diane J. Cook