Background: Predicting metabolic sites is important in the drug discovery process to aid in rapid compound optimisation. No interactive tool exists and most of the useful tools ar...
Lars Carlsson, Ola Spjuth, Samuel Adams, Robert C....
Background: Probing the complex fusion of genetic and environmental interactions, metabolic profiling (or metabolomics/metabonomics), the study of small molecules involved in meta...
Harriet J. Muncey, Rebecca Jones, Maria De Iorio, ...
Background: Genome-scale metabolic reconstructions under the Constraint Based Reconstruction and Analysis (COBRA) framework are valuable tools for analyzing the metabolic capabili...
Jan Schellenberger, Junyoung O. Park, Tom M. Conra...
It is widely recognized that complexity of metabolic networks arises from duplication, recruitment and recombination of enzyme protein domains. However, variations of the domain ev...
Metabolic flux estimation—the problem of finding out the rates of reactions in metabolic pathways—is an important problem area in the study of metabolism. The most accurate t...
Juho Rousu, Ari Rantanen, Hannu Maaheimo, Esa Pitk...
: Carbon Labeling Systems (CLS) are large equation systems that describe the dynamics of labeled carbon atoms in a metabolic network. The rapid solution of these systems is the alg...
Nicole Isermann, Michael Weitzel, Wolfgang Wiecher...
Abstract. Metabolic P systems, shortly MP systems, are a special class of P systems, introduced for expressing biological metabolism. Their dynamics are computed by metabolic algor...
—This paper presents a qualitative logic-based method for the steady-state analysis and revision of metabolic networks with inhibition. The approach is able to automatically revi...