BMCBI
2011
13 years 6 months ago
2011
Background: DNA methylation has been shown to play an important role in the silencing of tumor suppressor genes in various tumor types. In order to have a system-wide understandin...
BMCBI
2010
13 years 9 months ago
2010
Background: High-throughput profiling of DNA methylation status of CpG islands is crucial to understand the epigenetic regulation of genes. The microarray-based Infinium methylati...
BMCBI
2006
13 years 12 months ago
2006
Background: DNA methylation plays an important role in development and tumorigenesis by epigenetic modification and silencing of critical genes. The development of PCR-based methy...
BIOINFORMATICS
2006
13 years 12 months ago
2006
Motivation: Over 50% of human genes contain CpG islands in their 5'-regions. Methylation patterns of CpG islands are involved in tissue-specific gene expression and regulatio...
BMCBI
2008
13 years 12 months ago
2008
Background: There is great interest in probing the temporal and spatial patterns of cytosine methylation states in genomes of a variety of organisms. It is hoped that this will sh...
BMCBI
2008
13 years 12 months ago
2008
Background: Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role...
BMCBI
2008
13 years 12 months ago
2008
Background: DNA methylation is an important epigenetic modification of the genome. Abnormal DNA methylation may result in silencing of tumor suppressor genes and is common in a va...
BMCBI
2010
13 years 12 months ago
2010
Background: High-throughput DNA methylation arrays are likely to accelerate the pace of methylation biomarker discovery for a wide variety of diseases. A potential problem with a ...
BMCBI
2010
13 years 12 months ago
2010
Background: Methylation of CpG islands within the DNA promoter regions is one mechanism that leads to aberrant gene expression in cancer. In particular, the abnormal methylation o...