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JCC
2006
57views more  JCC 2006»
14 years 17 days ago
A search algorithm for fixed-composition protein design
: We present a computational protein design algorithm for finding low-energy sequences of fixed amino acid composition. The search algorithms used in protein design typically do no...
Geoffrey K. Hom, Stephen L. Mayo
JCC
2008
91views more  JCC 2008»
14 years 17 days ago
An improved pairwise decomposable finite-difference Poisson-Boltzmann method for computational protein design
Abstract: Our goal is to develop accurate electrostatic models that can be implemented in current computational protein design protocols. To this end, we improve upon a previously ...
Christina L. Vizcarra, Naigong Zhang, Shannon A. M...
BMCBI
2006
137views more  BMCBI 2006»
14 years 19 days ago
A maximum likelihood framework for protein design
Background: The aim of protein design is to predict amino-acid sequences compatible with a given target structure. Traditionally envisioned as a purely thermodynamic question, thi...
Claudia L. Kleinman, Nicolas Rodrigue, Céci...