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BMCBI
2008
151views more  BMCBI 2008»
13 years 11 months ago
An integrated database-pipeline system for studying single nucleotide polymorphisms and diseases
Background: Studies on the relationship between disease and genetic variations such as single nucleotide polymorphisms (SNPs) are important. Genetic variations can cause disease b...
Jin Ok Yang, Sohyun Hwang, Jeongsu Oh, Jong Bhak, ...
BMCBI
2008
93views more  BMCBI 2008»
13 years 11 months ago
Ranking single nucleotide polymorphisms by potential deleterious effects
Identifying single nucleotide polymorphisms (SNPs) that are responsible for common and complex diseases such as cancer is of major interest in current molecular epidemiology. Howe...
Phil Hyoun Lee, Hagit Shatkay
BMCBI
2008
119views more  BMCBI 2008»
13 years 11 months ago
Snagger: A user-friendly program for incorporating additional information for tagSNP selection
Background: There has been considerable effort focused on developing efficient programs for tagging single-nucleotide polymorphisms (SNPs). Many of these programs do not account f...
Christopher K. Edlund, Won H. Lee, Dalin Li, David...
BMCBI
2008
76views more  BMCBI 2008»
13 years 11 months ago
Empirical Bayes analysis of single nucleotide polymorphisms
Background: An important goal of whole-genome studies concerned with single nucleotide polymorphisms (SNPs) is the identification of SNPs associated with a covariate of interest s...
Holger Schwender, Katja Ickstadt
BMCBI
2010
95views more  BMCBI 2010»
13 years 11 months ago
Identifying main effects and epistatic interactions from large-scale SNP data via adaptive group Lasso
Background: Single nucleotide polymorphism (SNP) based association studies aim at identifying SNPs associated with phenotypes, for example, complex diseases. The associated SNPs m...
Can Yang, Xiang Wan, Qiang Yang, Hong Xue, Weichua...
BMCBI
2010
88views more  BMCBI 2010»
13 years 11 months ago
FastTagger: an efficient algorithm for genome-wide tag SNP selection using multi-marker linkage disequilibrium
Background: Human genome contains millions of common single nucleotide polymorphisms (SNPs) and these SNPs play an important role in understanding the association between genetic ...
Guimei Liu, Yue Wang, Limsoon Wong
BMCBI
2010
99views more  BMCBI 2010»
13 years 11 months ago
Assignment of chromosomal locations for unassigned SNPs/scaffolds based on pair-wise linkage disequilibrium estimates
Background: Recent developments of high-density SNP chips across a number of species require accurate genetic maps. Despite rapid advances in genome sequence assembly and availabi...
Mehar S. Khatkar, Matthew Hobbs, Markus Neuditschk...
BMCBI
2010
155views more  BMCBI 2010»
13 years 11 months ago
FunctSNP: an R package to link SNPs to functional knowledge and dbAutoMaker: a suite of Perl scripts to build SNP databases
Background: Whole genome association studies using highly dense single nucleotide polymorphisms (SNPs) are a set of methods to identify DNA markers associated with variation in a ...
Stephen J. Goodswen, Cedric Gondro, Nathan S. Wats...
ESA
2001
Springer
105views Algorithms» more  ESA 2001»
14 years 4 months ago
SNPs Problems, Complexity, and Algorithms
Abstract. Single nucleotide polymorphisms (SNPs) are the most frequent form of human genetic variation. They are of fundamental importance for a variety of applications including m...
Giuseppe Lancia, Vineet Bafna, Sorin Istrail, Ross...