Background: Successful realization of a "systems biology" approach to analyzing cells is a grand challenge for our understanding of life. However, current modeling appro...
Background: In systems biology, and many other areas of research, there is a need for the interoperability of tools and data sources that were not originally designed to be integr...
John Boyle, Christopher C. Cavnor, Sarah A. Killco...
Background: A growing demand for tools to assist the building and analysis of biological networks exists in systems biology. We argue that the use of a formal approach is relevant...
The collection of multiple genome-scale datasets is now routine, and the frontier of research in systems biology has shifted accordingly. Rather than clustering a single dataset t...
Balaji S. Srinivasan, Nigam H. Shah, Jason Flannic...
Genomes to Life (GTL), the U.S. Department of Energy Office of Science’s systems biology program, focuses on environmental microbiology. Over the next 10 to 20 years, GTL’s ke...
Marvin Frazier, David Thomassen, Aristides Patrino...
With the invention of microarray technology, researchers are able to measure the expression levels of ten thousands of genes in parallel at various time points of a biological proc...
Christian Spieth, Felix Streichert, Nora Speer, An...
What is systems biology? What can biologists gain from an attempt to algebraize the questions in systems biology? Starting with plausible biological theses, can one algebraically m...
This position paper argues that the operational modelling approaches from the formal methods community can be applied fruitfully within the systems biology domain. The results can ...
Nicola Bonzanni, K. Anton Feenstra, Wan Fokkink, E...