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NAR
2006
84views more  NAR 2006»
14 years 11 days ago
Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases
Individual zinc finger (ZF) domains that recognize DNA triplets with high specificity and affinity can be used to create designer transcription factors and nucleases that are spec...
Jeffrey G. Mandell, Carlos F. Barbas III
BMCBI
2006
82views more  BMCBI 2006»
14 years 15 days ago
Selection of antisense oligonucleotides based on multiple predicted target mRNA structures
Background: Local structures of target mRNAs play a significant role in determining the efficacies of antisense oligonucleotides (ODNs), but some structure-based target site selec...
Xiaochen Bo, Shaoke Lou, Daochun Sun, Wenjie Shu, ...
BIRD
2008
Springer
14 years 2 months ago
Translational Control by RNA-RNA Interaction: Improved Computation of RNA-RNA Binding Thermodynamics
The thermodynamics of RNA-RNA interaction consists of two components: the energy necessary to make a potential binding region accessible, i.e., unpaired, and the energy gained from...
Ulrike Mückstein, Hakim Tafer, Stephan H. F. ...