Frequency Distribution of TATA Box and Extension Sequences on Human Promoters

Background: TATA box is one of the most important transcription factor binding sites. But the exact sequences of TATA box are still not very clear. Results: In this study, we conduct a dedicated analysis on the frequency distribution of TATA Box and its extension sequences on human promoters. Sixteen TATA elements derived from the TATA Box motif, TATAWAWN, are classified into three distribution patterns: peak, bottom-peak, and bottom. Fourteen TATA extension sequences are predicted to be the new TATA Box elements due to their high motif factors, which indicate their statistical significance. Statistical analysis on the promoters of mice, zebrafish and drosophila melanogaster verifies seven of these elements. It is also observed that the distribution of TATA elements on the promoters of housekeeping genes are very similar with their distribution on the promoters of tissue specific genes in human. Conclusion: The dedicated statistical analysis on TATA box and its extension sequences yie...

• Type: Conference
• Year: 2006
• Where: IMSCCS
• Authors: Wei Shi, Wanlei Zhou
• Keywords: IMSCCS 2006, Tata Box, TATA Box Elements, TATA Elements