Statistical discrimination methods are suitable not only for classification but also for characterisation of differences between a reference group of patterns and the population under investigation. In the last years, statistical methods have been proposed to classify and analyse morphological and anatomical structures of medical images. Most of these techniques work in high-dimensional spaces of particular features such as shapes or statistical parametric maps and have overcome the difficulty of dealing with the inherent high dimensionality of medical images by analysing segmented structures individually or performing hypothesis tests on each feature separately. In this paper, we present a general multivariate linear framework to identify and analyse the most discriminating hyper-plane separating two populations. The goal is to analyse all the intensity features simultaneously rather than segmented versions of the data separately or feature-by-feature. The conceptual and mathematical...
Carlos E. Thomaz, Nelson A. O. Aguiar, Sergio H. A