In this paper, we present a novel deformable model for soft tissue simulation in a real-time manner. The innovative model consists of two submodels: the surface one and the internal one, which are based on Mass-Spring system and Medial Representation respectively. This proposed model is more accurate and efficient than the pure surface Mass-Spring one by taking advantages of Medial Representation to reflect inner attributes of soft tissue. We also optimize the Mass-Spring system in order to refine the appearance of soft tissue movement and reduce its complexity. A real clinical model using a segmented left-kidney is presented as an example in our case study.