Software inspection helps to improve the quality of software products early in the development process. For design inspection recent research showed that usage-based reading of documents is more effective and efficient than traditional checklists. Usage-based reading guides actively the inspector with pre-sorted use cases, while traditional checklists let the inspector figure out how best to proceed. This paper investigates the impact of active guidance on an inspection process: We introduced checklists that give the inspector a process to follow, which should be as flexible as traditional checklists but more efficient. We compared the performance of this approach in a controlled experiment in an academic environment with traditional checklist and usage-based reading. Main results of the investigation are (a) checklists with active guidance are significantly more efficient than traditional checklists for finding major defects and (b) usage-based reading is more effective and efficient ...