The Semantic Web has reached a level of maturity that allows RDF and OWL to be adopted by commercial software vendors. Products that incorporate these standards are being used to help provide solutions to the increasingly complex IT challenges that many industries face. Standardization efforts for the Semantic Web have progressed to the point where efforts are starting in the integration of ontologies and rules. This paper showcases the implementation of a Semantic Web rulebase in Oracle Database 10g, and provides examples of its use within drug discovery and development.