Discrete event network simulators have emerged as popular tools for verification and performance evaluation for various wireless networks. Nevertheless, the desire to model such networks at high fidelity implies high computational costs, prohibiting most researchers from simulating wireless networks with thousands of nodes. There have been attempts on performance optimizations for large-scale wireless network simulation, but they have not appropriately modeled accumulation of weak interference, thereby suffering inaccuracies which may be magnified by upper layer protocols. This paper presents analysis of the effects of common optimization techniques for large-scale wireless network simulation on the overall network performance and also proposes modifications and novel techniques that introduce only limited inaccuracies or no additional inaccuracy at all. The study quantifies the effects of those optimizations on the simulation results for given thresholds and network parameter...