We consider parameterized problems where some separation property has to be achieved by deleting as few vertices as possible. The following five problems are studied: delete k vertices such that (a) each of the given ℓ terminals is separated from the others, (b) each of the given ℓ pairs of terminals is separated, (c) exactly ℓ vertices are cut away from the graph, (d) exactly ℓ connected vertices are cut away from the graph, (e) the graph is separated into at least ℓ components. We show that if both k and ℓ are parameters, then (a), (b) and (d) are fixed-parameter tractable, while (c) and (e) are W[1]-hard.