Automatic Locating the Centromere on Human Chromosome Pictures

Many genetic disorders or possible abnormalities that may occur in the future generations can be predicted through analyzing the shape and morphological characteristics of the chromosomes. Karyotype (a systemized array of the human chromosomes obtained from a single cell either by drawing or by photography using a light microscope [1]) is often used for this purpose. To make a Karyotype it is necessary to identify each one of the 24 chromosomes (22 autosomal and a pair of sex chromosomes) from the microscopic images. The first step to automate this process is then to define the morphological and band pattern based features for each chromosome An important class of morphological features includes those defined with respect to the location of the chromosome’s centromere (part of the chromosome that divides it to the long and short arms). Therefore, localization of centromere is an initial step in designing an automatic karyotyping system. In this paper, an effective algorithm for chro...

• Type: Conference
• Year: 2003
• Where: CBMS
• Authors: Mehdi Moradi, Seyed Kamaledin Setarehdan, S. R. Ghaffari
• Keywords: CBMS 2003, Chromosome, Chromosome Image Processing, Chromosome Images, Medical Imaging