Statistial Analysis of nucleosome occupancy and histone modification data

Abstract-- In eukaryotic cells, genomic DNAs wrap around beadlike molecules, called nucleosomes, so as to pack more compactly in the nucleus of the cell. The nucleosome is made up of four pairs of histone proteins (H2A, H2B, H3, and H4) who share a very similar structrual motif. The positioning of nucleosomes as well as the modifications of various positions of the histone proteins (such as acetylation, methylation, etc.) play important but incompletely understood roles in gene regulation. Here we describe some statistical models we developed for predicting nucleosome positioning and histone modification patterns using only genomic sequence information. The regulation of DNA accessibility through nucleosome positioning is important for transcription control. Computation models have been developed to predict genome-wide nucleosome positions from DNA sequences, but these models consider only nucleosome sequences, which may have limited their power. We developed a statistical multi-resolu...

• Type: Conference
• Year: 2007
• Where: BIBE
• Authors: Guo-Cheng Yuan, Jun S. Liu
• Keywords: BIBE 2007, Bioinformatics, Histone Proteins, Nucleosome Positioning, Sequence Information