Discovering Novel Interacting Motif Pairs from Large Protein-Protein Interaction Datasets

Current motif discovery methods can only detect individual motifs in groups of protein sequences--they do not discover potentially-interacting motif pairs underlying the interactions between the proteins. Such interacting motif pairs can be useful for the design and discovery of new drugs. Recent technological advances have made available large datasets of experimentallydetected protein-protein interactions. The functionally-induced co-occurring patterns inherent in the pairwise protein interaction data can be exploited to discover novel interacting motif pairs. In this work, we present an automated method to discover novel interacting motif pairs from large datasets of protein-protein interactions. Using our method, we discovered 9,045 novel 1 

• Type: Conference
• Year: 2004
• Where: BIBE
• Authors: Soon-Heng Tan, Wing-Kin Sung, See-Kiong Ng
• Keywords: BIBE 2004, Bioinformatics, Motif Pairs, Potentially-interacting Motif Pairs, Such Interacting Motif