We address the life cycle of semantic web based knowledge management from ontology modelling to instance generation and reuse. We illustrate through a semantic web based knowledge management approach the potential of applying semantic web technologies in GEODISE, an e-Science pilot project in the domain of Engineering Design Search and Optimization (EDSO). In particular, we show how ontologies and semantically enriched instances are acquired through knowledge acquisition and resource annotation. This is illustrated not only in Prot