A framework is proposed to manage the distributed and heterogeneous databases in grid environment for understanding protein-protein interaction. Furthermore, the framework is used into bioinformatics division of Shanghai Research and Development Public Service Platform. In this paper, the need of data integration and the related works are discussed first, followed by a brief analysis of the requirement of grid-enabled data integration framework. In the third part, the grid enabled integration framework is put forward in detail. At last, one case for bioinformatics research based on the framework is given out to show the benefits of the framework for bioinformatics research. Key words: Protein-Protein Interaction, OGSA-DAI, Activity, Metadata Catalog