Different modalities in biomedical imaging, like CT, MRI and PET scanners, provide detailed crosssectional views of the human anatomy. The imagery obtained from these scanning devices are typically large-scale data sets whose sizes vary from several hundred megabytes to about one hundred gigabytes, making them impossible to be stored on a regular local hard drive. San Diego Supercomputer Center (SDSC) maintains a High-Performance Storage System (HPSS) where these large-scale data sets can be stored. Members of the National Partnership for Advanced Computational Infrastructure (NPACI) have implemented a Scalable Visualization Toolkit (Vistools), which is used to access the data sets stored on HPSS and also to develop different applications on top of the toolkit. 2-D cross-sectional images are extracted from the data sets stored on HPSS using Vistools, and these 2-D cross-sections are then transformed into smaller hierarchical representations using a wavelet transformation. This makes i...