The use of the Operation Process Simulation (OPS) for Six Sigma Projects (SSP) can illustrate visual display of the process by enabling to define, measure, analyze and improve the current process virtually but realistically. This paper investigates the quantitative benefits of using the Design for Six Sigma (DFSS) technique for a SSP in a Mining and Iron Production Factory (MIPF). The DFSS was deployed through five distinct phases: DMAIC, for optimizing the current MIPF as a first part of the research. The second part of the research investigates the possibilities of developing the deliverables of the DMAIC for a DMADV for implementing a new MIPF. Use of the OPS in all phases of the DMAIC has provided highly effective and accurate prediction for factory process improvement. Furthermore, the paper explored the effective possibilities of developing the deliverables of the DMAIC for the DMADV for building new MIPF.