The need for interoperability of information systems among supply chain partners has been recognized. A number of standards have been or are being developed to ensure interoperability of applications used along the supply chain. An associated need for interoperability testing has emerged. There is a need to evaluate compliance of applications to standards across specific platforms. The standards themselves need to be evaluated for a comprehensive coverage of the application scope (validation testing). This paper reports on a distributed simulation based approach for supply chain interoperability testing. Simulations are used to represent real life organizations to serve as sources and consumers of dynamic data. The data can be encapsulated per the standard under consideration and exchanged with other organizations directly or through selected applications for testing. Error free performance of the simulated systems over time will provide confidence in the interoperability of applicati...