In this paper we present a framework and methodology for aligning the business strategy and IT/IS for an organization offering an e-service in a multi-organizational setting. We explore three perspectives on the e-service to be offered: 1) The business strategy perspective, in terms of the organization's strategic position; 2) The value creation perspective, in terms of a networked value constellation enabling value creation; 3) The IT/IS perspective, in terms of an IT architecture enabling the provision of the e-service. We explore these three perspective and modify them, until we find a situation in which 1) the designed IT architecture enables the provision of the e-service and can be implemented in a profitable way by the networked value constellation, and 2) the enterprise under study is positioned in the networked value constellation such that the enterprise can execute its business strategy. We have tested our approach on a starting enterprise offering a mobile e-service.