In the Linked Open Data cloud one of the largest data sets, comprising of 2.5 billion triples, is derived from the Life Science domain. Yet this represents a small fraction of the total number of publicly available data sources on the Web. We briefly describe past attempts to transform specific Life Science sources from a plethora of open as well as proprietary formats into RDF data. In particular, we identify and tackle two bottlenecks in current practice: Acquiring ontologies to formally describe these data and creating “RDFizer” programs to convert data from legacy formats into RDF. We propose an unsupervised method, based on transformation rules, for performing these two key tasks, which makes use of our previous work on unsupervised wrapper induction for extracting labelled data from complete Life Science Web sites. We apply our approach to 13 real-world online Life Science databases. The learned ontologies are evaluated by domain experts as well as against gold standard ont...