Medical Information Systems (MIS) in general, like any other complex and large system, can be based on centralized or distributed DBMS. Centralized system is much easier for implementation and administration, but the benefits of distributed over centralized system are various. Load balance of the system is evenly, and when it comes to the internet connections interruption, system continues to work inside its remote nodes. However, database replication between DBMS's, considering the fact that larger Health Care Facilities in Serbia are consisted of at least 70-80 remote clinics, can be a huge problem. All well-known database replications are platform-dependent, and when it comes to the possible replacement of the platform the world known problem of setting replication on different platforms is born (MS SQL Server, Oracle, PostgreSQL, MySQL...). Considering that, we have developed one platform-independent IS-dependent database replication solution that can enable fast replication e...