A Grid based e-Research platform is being developed for providing a simulation-based virtual reality environment for clinical management and therapy treatment. The development of this platform involves cross-disciplinary experts aiming at combining the state-of-the-art Computational Fluid Dynamics (CFD) analysis tools into clinical management system. These fluid dynamic studies support the physician and surgeon with recommendations for the possible range of treatment and operation techniques. The platform will consist of a cluster of computing nodes, a middleware (Grid management layer), internet accessible tomography data and CFD analysis tools, and a tailored graphical user interface (GUI) application for various experts. In future, this platform will provide the novel creation of a prototype virtual reality model environment that links each technical modular consisting of a consolidation system with flexible interface model for exchanging data efficiently. Furthermore, besides allo...