Abstract. In this paper we propose a structured approach for the simulation of the human body which is comprehensive and extendable. Our architecture resembles the human organism as defined by the systematic and functional anatomy to integrate a broad range of simulation algorithms. To share common data and to create interlinks between algorithms without modifying the algorithms themselves we introduce abstract control entities that mimic the basic setup of physiological systems. We utilize the model-view-controller pattern to establish a separation of algorithms and data. The structure was designed for the purpose of interactive simulation of the human body in virtual environments.