Open answers in questionnaires contain valuable information that is very time-consuming to analyze manually. We present a method for hypothesis generation from questionnaires based on text clustering. Text clustering is used interactively on the open answers, and the user can explore the cluster contents. The exploration is guided by automatic evaluation of the clusters against a closed answer regarded as a categorization. This simplifies the process of selecting interesting clusters. The user formulates a hypothesis from the relation between the cluster content and the closed answer categorization. We have applied our method on an open answer regarding occupation compared to a closed answer on smoking habits. With no prior knowledge of smoking habits in different occupation groups we have generated the hypothesis that farmers smoke less than the average. The hypothesis is supported by several separate surveys. Closed answers are easy to analyze automatically but are restricted and ma...