The Ontology Web Language (OWL) provides a powerful framework for describing the semantics and constraints of a particular domain described in RDF. Along with that power comes the burden of a learning curve that is often inherited by the tools used to manage OWL ontologies. The Manchester OWL syntax introduced an intuitive syntax for the presentation and editing of OWL ontologies that attempted to address some of this burden for the benefit of authors. One of the major design decisions of this syntax was the adoption of an infix notation. The primary contribution of this paper is a native, idiomatic API for constructing and manipulating OWL in Python that builds on the strengths of the Manchester OWL syntax. It is called InfixOWL.