Multiple disorders are a daily problem in medical diagnosis and treatment. However, case-based diagnosis handling multiple disorders is still a challenging task. Although case-based reasoning has been applied successfully in medical domains, the handling of multiple disorders is often not sufficient. In this paper, we investigate three improved approaches for handling multiple disorders in case-based diagnosis. The methods are evaluated with a medical case base taken from a real world application. The context of our work is to supplement a medical documentation and consultation system by CBR techniques for experience management.