: In the complete graph K2m+3 for m 2, we study some structures of simple non-isomorphic Hamiltonian sub-graphs of the form H ( 2m+3 , 6m+3) for m 2 . The various structures of the form H(2m+3, 6m+3) for m 2 are found and some of them are observed to give some forms of metal atom cluster compound of chemistry . Finally, we establish an algorithm to solve the traveling salesman problem when the weights of edges of the complete graph K 2m+3 for m 2 are non-repeated in the case of symmetrical problems. The applications of the sub-graphs H (2m+3,6m+3) for m 2 are shown in the solution of traveling salesman problem . Keywords- Complete graph, Hamiltonian simple sub-graph, Non-isomorphic graph, cluster compounds, Tsp .