Genomic Fold Assignment and Rational Modeling of Proteins of Biological Interest

The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.

• Type: Conference
• Year: 2000
• Where: ISMB
• Authors: J. Michael Sauder, Roland L. Dunbrack Jr.
• Keywords: Computational Biology, ISMB 2000, Multicellular Organism, Protein Fold Assignment, Rational Structure Modeling