Exploratory Identification of Image-Based Biomarkers for Solid Mass Pulmonary Tumors

If imaging is to serve as a valid biomarker in the assessment of the response of cancer to therapies, a reproducible and predictive radiologic metric is required. A biomarker is an indicator of a biological property that can be used to measure the progress of disease. While current size-based, quantitative techniques provide numerical representations of tumors, they are not necessarily indicative of disease progression for advanced cancers. In this paper, we present an end-to-end process to explore the use of other image-based features especially statistical textural features for cancer change detection. We exploit the earth mover's distance metric for measuring the change in the tumor burden over a period, between the time the baseline scans were taken, and the time the therapy response scans were taken. The time-to-progression (TTP) of the disease is our known patient outcome. We analyze the correlations between TTP and our change measurements and discover that the local texture...

• Type: Conference
• Year: 2008
• Where: MICCAI
• Authors: Ifeoma Nwogu, Jason J. Corso
• Keywords: Disease Progression, Medical Imaging, MICCAI 2008, Predictive Radiologic Metric, Tumor Burden Size