An important question in behavioral epidemiology and public health is to understand how individual behavior is affected by illness and stress. Although changes in individual behavior are intertwined with contagion, epidemiologists today do not have sensing or modeling tools to quantitatively measure its effects in real-world conditions. In this paper, we propose a novel application of ubiquitous computing. We use mobile phone based co-location and communication sensing to measure characteristic behavior changes in symptomatic individuals, reflected in their total communication, interactions with respect to time of day (e.g., late night, early morning), diversity and entropy of face-to-face interactions and movement. Using these extracted mobile features, it is possible to predict the health status of an individual, without having actual health measurements from the subject. Finally, we estimate the temporal information flux and implied causality between physical symptoms, behavior and...