Artificial Immune System (AIS) is taken into account from evolutionary algorithms that have been inspired from defensive mechanism of complex natural immune system. For using this algorithm like other evolutionary algorithms, it should be regulated many parameters, which usually they confront researchers with difficulties. Also another weakness of AIS especially in multimodal problems is trapping in local minima. In basic method, mutation rate changes as only and most important factor results in convergence rate changes and falling in local optima. This paper presented two hybrid algorithm using learning automata to improve the performance of AIS. In the first algorithm entitled LA-AIS has been used one learning automata for tuning the hypermutation rate of AIS and also creating a balance between the process of global and local search. In the second algorithm entitled LA-CAIS has been used two learning automata for cooperative antibodies in the evolution process. Experimental results o...