BisoGenet: a new tool for gene network building, visualization and analysis

Background: The increasing availability and diversity of omics data in the post-genomic era offers new perspectives in most areas of biomedical research. Graph-based biological networks models capture the topology of the functional relationships between molecular entities such as gene, protein and small compounds and provide a suitable framework for integrating and analyzing omics-data. The development of software tools capable of integrating data from different sources and to provide flexible methods to reconstruct, represent and analyze topological networks is an active field of research in bioinformatics. Results: BisoGenet is a multi-tier application for visualization and analysis of biomolecular relationships. The system consists of three tiers. In the data tier, an in-house database stores genomics information, protein-protein interactions, protein-DNA interactions, gene ontology and metabolic pathways. In the middle tier, a global network is created at server startup, represent...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Alexander Martin, Maria Elena Ochagavia, Laya C. Rabasa, Jamilet Miranda, Jorge Fernandez-de-Cossio, Ricardo Bringas
• Keywords: Biological Networks, BMCBI 2010, Graph-based Biological Networks, Tier