Simulation of a Petri net-based Model of the Terpenoid Biosynthesis Pathway

Background: The development and simulation of dynamic models of terpenoid biosynthesis has yielded a systems perspective that provides new insights into how the structure of this biochemical pathway affects compound synthesis. These insights may eventually help identify reactions that could be experimentally manipulated to amplify terpenoid production. In this study, a dynamic model of the terpenoid biosynthesis pathway was constructed based on the Hybrid Functional Petri Net (HFPN) technique. This technique is a fusion of three other extended Petri net techniques, namely Hybrid Petri Net (HPN), Dynamic Petri Net (HDN) and Functional Petri Net (FPN). Results: The biological data needed to construct the terpenoid metabolic model were gathered from the literature and from biological databases. These data were used as building blocks to create an HFPNe model and to generate parameters that govern the global behaviour of the model. The dynamic model was simulated and validated against kno...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Aliah Hazmah Hawari, Zeti-Azura Mohamed-Hussein
• Keywords: BMCBI 2010, Dynamic Model, Petri Net, Terpenoid