TimeDelay-ARACNE: Reverse engineering of gene networks from time-course data by an information theoretic approach

Background: One of main aims of Molecular Biology is the gain of knowledge about how molecular components interact each other and to understand gene function regulations. Using microarray technology, it is possible to extract measurements of thousands of genes into a single analysis step having a picture of the cell gene expression. Several methods have been developed to infer gene networks from steady-state data, much less literature is produced about time-course data, so the development of algorithms to infer gene networks from time-series measurements is a current challenge into bioinformatics research area. In order to detect dependencies between genes at different time delays, we propose an approach to infer gene regulatory networks from time-series measurements starting from a well known algorithm based on information theory. Results: In this paper we show how the ARACNE (Algorithm for the Reconstruction of Accurate Cellular Networks) algorithm can be used for gene regulatory ne...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Pietro Zoppoli, Sandro Morganella, Michele Ceccarelli
• Keywords: Algorithm, BMCBI 2010, Gene, Gene Regulatory Network