This paper aims to offer an overview of the meaning of autonomy for biological individuals and artificial models rooted in a specific perspective that pays attention to the historical and structural aspects of its origins and evolution. Taking autopoiesis and the recursivity characteristic of its circular logic as a starting point, we depart from some of its consequences to claim that the theory of autonomy should also take into account those historical and structural features. Autonomy should not be considered only in internal or constitutive terms, but the largely neglected interactive aspects stemming from it should be equally addressed. This approach makes it possible to develop better suggestions for work on artificial models, but the main goal of this activity should not be to produce artificial autonomous systems, but to get a better understanding of the role of autonomy for life and the varieties of its organization and phenomenological diversity. Keywords Agency, biological o...