Examination of the relationship between essential genes in PPI network and hub proteins in reverse nearest neighbor topology

Background: In many protein-protein interaction (PPI) networks, densely connected hub proteins are more likely to be essential proteins. This is referred to as the "centrality-lethality rule", which indicates that the topological placement of a protein in PPI network is connected with its biological essentiality. Though such connections are observed in many PPI networks, the underlying topological properties for these connections are not yet clearly understood. Some suggested putative connections are the involvement of essential proteins in the maintenance of overall network connections, or that they play a role in essential protein clusters. In this work, we have attempted to examine the placement of essential proteins and the network topology from a different perspective by determining the correlation of protein essentiality and reverse nearest neighbor topology (RNN). Results: The RNN topology is a weighted directed graph derived from PPI network, and it is a natural repr...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Kang Ning, Hoong Kee Ng, Sriganesh Srihari, Hon Wai Leong, Alexey I. Nesvizhskii
• Keywords: BMCBI 2010, Essential Proteins, Ppi Network, Proteins